| ID |
U0039 |
|
| Creation Date |
27 July 2004 |
| Updating Date |
27 July 2004 |
|
| Standard Name |
Granulocyte colony-stimulating factor stem-loop destabilizing element (G-CSF_SLDE) |
| UTRSite Pattern |
r1={au,ua,gc,cg}
ansym p1=tgtttaa tat r1~p1 smag |
|
| UTR Region |
3' |
| Taxon Range |
Metazoa |
|
| Description |
Granulocyte colony-stimulating factor (G-CSF) is secreted in response to the inflammatory mediators IL-1 and TNF-alpha and by activated macrophages. The synthesis of G-CSF is regulated at the post-transcriptional level through the control of mRNA stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilized in response to IL-1 or TNF-alpha, and also in the case of monocytes and macrophages, in response to LPS.
G-CSF 3'UTR mRNA contains two types of cis-acting destabilizing elements. In addition to several copies of the AU-rich element (ARE) it contains another destabilizing element whose activity resides in a stem-loop structure, whose consensus sequence has been determined by site-directed mutagenesis. The stem is 8 nt long (or 7 nt in chicken) with a conserved YAU loop.
The destabilizing activity consists in the enhancing of deadenylation rate.
|
|
|
|
| Feature Key |
G-CSF_SLDE |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3' UTR in Bos taurus colony stimulating factor 3 (granulocyte) (CSF3), mRNA. |
Bos taurus |
UTRef: 3BTAR001716 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Bos taurus colony stimulating factor 3 (granulocyte) (CSF3), mRNA. |
Bos taurus |
RefSeq: NM_174028 |
[T1] |
|
| Gene(s) |
| Description |
Species |
Link |
Ref. |
| colony stimulating factor 3 (granulocyte) (CSF3). |
Bos taurus |
EntrezGene: 281096 |
[G1] |
|
|
| ID |
[1] |
| Authors |
Putland RA, Sassinis TA, Harvey JS, Diamond P, Coles LS, Brown CY, Goodall GJ |
| Title |
RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation. |
| Citation |
Mol Cell Biol 2002;22:1664-1673. |
| Year |
2002 |
| ID |
[U1] |
| Authors |
Putland RA, Sassinis TA, Harvey JS, Diamond P, Coles LS, Brown CY, Goodall GJ |
| Title |
RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation. |
| Citation |
Mol Cell Biol 2002;22:1664-1673. |
| Year |
2002 |
| ID |
[T1] |
| Authors |
Putland RA, Sassinis TA, Harvey JS, Diamond P, Coles LS, Brown CY, Goodall GJ |
| Title |
RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation. |
| Citation |
Mol Cell Biol 2002;22:1664-1673. |
| Year |
2002 |
| ID |
[G1] |
| Authors |
Putland RA, Sassinis TA, Harvey JS, Diamond P, Coles LS, Brown CY, Goodall GJ |
| Title |
RNA destabilization by the granulocyte colony-stimulating factor stem-loop destabilizing element involves a single stem-loop that promotes deadenylation. |
| Citation |
Mol Cell Biol 2002;22:1664-1673. |
| Year |
2002 |
