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::General Information
ID U0040
Creation Date 27 July 2004
Updating Date 27 July 2004
Standard Name Renin stability regulatory element (Ren_SRE)
UTRSite Pattern
uk 0...1  p1=cuuu  rrggrm 0...3 aaa 0...4 auaaagayuncauguu
::Taxonomy
UTR Region 3'
Taxon Range Vertebrata
::Description
Description Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, inducing the production of angiotensin II and initiating a cascade of reactions that results in an elevation of blood pressure and increased sodium retention by the kidney. Renin (REN) mRNA stability is modulated by a cis-acting element, about 35 nt long, located in the 3'UTR. This element, that contributes to basal REN mRNA instability, is the target of a numbe......
::Features
Feature Key Ren_SRE
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3' UTR in Homo sapiens renin (REN), mRNA. Homo sapiens UTRef: 3HSAR027384 [U1]
Transcript(s)
Description Species Link Ref.
Homo sapiens renin (REN), mRNA. Homo sapiens RefSeq: NM_000537 [T1]
Gene(s)
Description Species Link Ref.
REN, renin. Homo sapiens EntrezGene: 5972 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
HADHB hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit Homo sapiens Homo sapiens RefSeq: NP_000174
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) Homo sapiens. Homo sapiens RefSeq: NP_001410
::References
ID [1]
Authors Adams DJ, Beveridge DJ, Van Der Weyden L, Mangs H, Leedman PJ, MorrisBJ
Title HADHB, HuR, and CP1 Bind to the Distal 3'-Untranslated Region ofHuman Renin mRNA and Differentially Modulate Renin Expression.
Citation J Biol Chem 2003;278:44894-44903.
Year 2003
ID [U1]
Authors Adams DJ, Beveridge DJ, Van Der Weyden L, Mangs H, Leedman PJ, MorrisBJ
Title HADHB, HuR, and CP1 Bind to the Distal 3'-Untranslated Region ofHuman Renin mRNA and Differentially Modulate Renin Expression.
Citation J Biol Chem 2003;278:44894-44903.
Year 2003
ID [T1]
Authors Adams DJ, Beveridge DJ, Van Der Weyden L, Mangs H, Leedman PJ, MorrisBJ
Title HADHB, HuR, and CP1 Bind to the Distal 3'-Untranslated Region ofHuman Renin mRNA and Differentially Modulate Renin Expression.
Citation J Biol Chem 2003;278:44894-44903.
Year 2003
ID [G1]
Authors Adams DJ, Beveridge DJ, Van Der Weyden L, Mangs H, Leedman PJ, MorrisBJ
Title HADHB, HuR, and CP1 Bind to the Distal 3'-Untranslated Region ofHuman Renin mRNA and Differentially Modulate Renin Expression.
Citation J Biol Chem 2003;278:44894-44903.
Year 2003