Signal Manager :: View

::General Information

ID U0040

Creation Date 27 July 2004

Updating Date 27 July 2004

Standard Name Renin stability regulatory element (Ren_SRE)

UTRSite Pattern

uk 0...1  p1=cuuu  rrggrm 0...3 aaa 0...4 auaaagayuncauguu

::Taxonomy

UTR Region 3'

Taxon Range Vertebrata

::Description

Description Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, inducing the production of angiotensin II and initiating a cascade of reactions that results in an elevation of blood pressure and increased sodium retention by the kidney. Renin (REN) mRNA stability is modulated by a cis-acting element, about 35 nt long, located in the 3'UTR. This element, that contributes to basal REN mRNA instability, is the target of a numbe......

::Features

Feature Key Ren_SRE

::Transcript(s) / Gene(s)

UTR(s)

Description	Species	Link	Ref.
3' UTR in Homo sapiens renin (REN), mRNA.	Homo sapiens	UTRef: 3HSAR027384	[U1]

Transcript(s)

Description	Species	Link	Ref.
Homo sapiens renin (REN), mRNA.	Homo sapiens	RefSeq: NM_000537	[T1]

Gene(s)

Description	Species	Link	Ref.
REN, renin.	Homo sapiens	EntrezGene: 5972	[G1]

::Protein(s)

Binding Protein(s)

Description	Species	Link	Ref.
HADHB hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit Homo sapiens	Homo sapiens	RefSeq: NP_000174
ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) Homo sapiens.	Homo sapiens	RefSeq: NP_001410

::References

ID [1]

Authors Adams DJ, Beveridge DJ, Van Der Weyden L, Mangs H, Leedman PJ, MorrisBJ

Title HADHB, HuR, and CP1 Bind to the Distal 3'-Untranslated Region ofHuman Renin mRNA and Differentially Modulate Renin Expression.

Citation J Biol Chem 2003;278:44894-44903.

Year 2003

ID [U1]

Authors Adams DJ, Beveridge DJ, Van Der Weyden L, Mangs H, Leedman PJ, MorrisBJ

Title HADHB, HuR, and CP1 Bind to the Distal 3'-Untranslated Region ofHuman Renin mRNA and Differentially Modulate Renin Expression.

Citation J Biol Chem 2003;278:44894-44903.

Year 2003

ID [T1]

Authors Adams DJ, Beveridge DJ, Van Der Weyden L, Mangs H, Leedman PJ, MorrisBJ

Title HADHB, HuR, and CP1 Bind to the Distal 3'-Untranslated Region ofHuman Renin mRNA and Differentially Modulate Renin Expression.

Citation J Biol Chem 2003;278:44894-44903.

Year 2003

ID [G1]

Authors Adams DJ, Beveridge DJ, Van Der Weyden L, Mangs H, Leedman PJ, MorrisBJ

Title HADHB, HuR, and CP1 Bind to the Distal 3'-Untranslated Region ofHuman Renin mRNA and Differentially Modulate Renin Expression.

Citation J Biol Chem 2003;278:44894-44903.

Year 2003