| ID |
U0041 |
|
| Creation Date |
12 July 2006 |
| Updating Date |
28 September 2009 |
|
| Standard Name |
PTH 3'UTR proximal cis-acting instability element (PTH1) |
| UTRSite Pattern |
TGYTVTASACAGBRTARGGCAA |
|
|
| UTR Region |
3' |
| Taxon Range |
Vertebrata |
|
| Description |
PTH (parathyroid hormone) mRNA stability, dependent on calcium/phosphate concentration, is mediated by the interaction of trans-acting proteins with cis-acting elements located in the 3'UTR (Bell et al. 2005).
A distal element has been characterized in rat and is conserved in human, dog, cat and mouse. This distal element is missing in cow and pig PTH mRNAs where its destabilizing activity is replaced by a proximal elements whose function has been assayed on a reporter gene. The proximal element is conserved in other species including human, horse, dog and cat but not always is functional, like in human. |
|
|
|
| Feature Key |
PTH1 |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3'UTR in Bos taurus parathyroid hormone (PTH), mRNA. |
Bos taurus |
UTRef: 3BTAR005998 |
[U1] |
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Bos taurus parathyroid hormone (PTH), mRNA. |
Bos taurus |
RefSeq: NM_173954 |
|
|
| Gene(s) |
|
|
| ID |
[1] |
| Authors |
Bell O, Silver J, Naveh-Many T. |
| Title |
Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region. |
| Citation |
J Bone Miner Res. 2005 May;20(5):858-66. |
| Year |
2005 |
| ID |
[U1] |
| Authors |
Bell O, Silver J, Naveh-Many T. |
| Title |
Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region. |
| Citation |
J Bone Miner Res. 2005 May;20(5):858-66. |
| Year |
2005 |
