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::General Information
ID U0041
Creation Date 12 July 2006
Updating Date 28 September 2009
Standard Name PTH 3'UTR proximal cis-acting instability element (PTH1)
UTRSite Pattern
TGYTVTASACAGBRTARGGCAA
::Taxonomy
UTR Region 3'
Taxon Range Vertebrata
::Description
Description PTH (parathyroid hormone) mRNA stability, dependent on calcium/phosphate concentration, is mediated by the interaction of trans-acting proteins with cis-acting elements located in the 3'UTR (Bell et al. 2005). A distal element has been characterized in rat and is conserved in human, dog, cat and mouse. This distal element is missing in cow and pig PTH mRNAs where its destabilizing activity is replaced by a proximal elements whose function has been assayed on a reporter gene. The proximal eleme......
::Features
Feature Key PTH1
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
3'UTR in Bos taurus parathyroid hormone (PTH), mRNA. Bos taurus UTRef: 3BTAR005998 [U1]
Transcript(s)
Description Species Link Ref.
Bos taurus parathyroid hormone (PTH), mRNA. Bos taurus RefSeq: NM_173954
Gene(s)
Description Species Link Ref.
Parathyroid hormone precursor (Parathyrin) (PTH) Bos taurus ENSEMBL: ENSBTAG00000019080
::References
ID [1]
Authors Bell O, Silver J, Naveh-Many T.
Title Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region.
Citation J Bone Miner Res. 2005 May;20(5):858-66.
Year 2005
ID [U1]
Authors Bell O, Silver J, Naveh-Many T.
Title Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region.
Citation J Bone Miner Res. 2005 May;20(5):858-66.
Year 2005