| ID |
U0042 |
|
| Creation Date |
12 July 2006 |
| Updating Date |
24 September 2009 |
|
| Standard Name |
PTH 3'UTR distal cis-acting instability element (PTH2) |
| UTRSite Pattern |
RTWKNYTMTTCTTTTTAAAGTA |
|
|
| UTR Region |
3' |
| Taxon Range |
Vertebrata |
|
| Description |
PTH (parathyroid hormone) mRNA stability, dependent on calcium/phosphate concentration, is mediated by the interaction of trans-acting proteins with cis-acting elements located in the 3'UTR (Bell et al., 2005). A distal element has been characterized in rat and is conserved in human, dog, cat and mouse. This distal element is missing in cow and pig PTH mRNAs where its destabilizing activity is replaced by a proximal elements whose function has been assayed on a reporter gene. Two trans-acting fa...... |
|
|
|
| Feature Key |
PTH2 |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| 3'UTR in Rattus norvegicus parathyroid hormone (Pth), mRNA. |
Rattus norvegicus |
UTRef: 3RNOR019009 |
|
|
| Transcript(s) |
| Description |
Species |
Link |
Ref. |
| Rattus norvegicus parathyroid hormone (Pth), mRNA. |
Rattus norvegicus |
RefSeq: NM_017044 |
|
|
| Gene(s) |
|
|
| Binding Protein(s) |
|
|
| ID |
[1] |
| Authors |
Bell O, Silver J, Naveh-Many T. |
| Title |
Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3'-untranslated region. |
| Citation |
J Bone Miner Res. 2005 May;20(5):858-66. |
| Year |
2005 |
| ID |
[B1] |
| Authors |
Sela-Brown A, Silver J, Brewer G, Naveh-Many T. |
| Title |
Identification of AUF1 as a parathyroid hormone mRNA 3'-untranslated region-binding protein that determines parathyroid hormone mRNA stability |
| Citation |
J Biol Chem. 275(10):7424-9. |
| Year |
2000 |
| ID |
[B2] |
| Authors |
Bell O, Gaberman E, Kilav R, Levi R, Cox KB, Molkentin JD, Silver J, Naveh-Many T. |
| Title |
The protein phosphatase calcineurin determines basal parathyroid hormone gene expression |
| Citation |
Mol Endocrinol. 19(2):516-26 |
| Year |
2005 |
| ID |
[B3] |
| Authors |
Dinur M, Kilav R, Sela-Brown A, Jacquemin-Sablon H, Naveh-Many T. |
| Title |
In vitro evidence that upstream of N-ras participates in the regulation of parathyroid hormone messenger ribonucleic acid stability. |
| Citation |
Mol Endocrinol. 20(7):1652-60. |
| Year |
2006 |
