UTRSite Logo
user: guest

Signal Manager :: View

::General Information
ID U0045
Creation Date 08 August 2007
Updating Date 24 September 2009
Standard Name ApoB 5'UTR cis-acting regulatory element
UTRSite Pattern
yragtnccynyctsrgyk 0...1 chgyckcnganganccngymsagcmagcmrs 0...1 gssgckaggccsrkg 0...6 ccaggccrcagccmrgragccrcccyacc 0...2 kcmryysgc
::Taxonomy
UTR Region 5'
Taxon Range Vertebrata
::Description
Description
Apolipoprotein B100 (apoB) is an important protein synthesized in liver that mediate uptake and clearance of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) from plasma. Increased levels of VLDL and LDL in plasma correlate with the development of coronary artery diseases and atherosclerosis.
The translation efficiency of human apoB mRNA is increased by a cis-regulatory element located in the 5'UTR (Pontrelli et al., 2004). The human apoB 5'UTR is 128 nucleotides long, 76% GC rich, and has several predicted stem loop structures. Recent studies indicated that insulin regulates apoB mRNA translation by decreasing translational efficiency through the apoB 5′UTR. This regulatory activity may involve the binding of a 110-kDa trans-acting protein factor, which is observed to decrease in the presence of insulin (Sidiropoulos et al., 2007).
The apoB 5'UTR is remarkably conserved in chimp (XM_001141877), rhesus (XM_001097500), mouse (BC038263) and rat (CB705521) apoB mRNAs, even if apparently there is no significant structural conservation as determined by RNAz application.
::Features
Feature Key ApoB
::Database Cross-references
Link
RFAM: RF00463
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
Apolipoprotein B (ApoB) Homo sapiens UTRef: 5HSAR030952 [U1][U2]
Transcript(s)
Description Species Link Ref.
Apolipoprotein B (ApoB) Homo sapiens RefSeq: NM_000384 [T1][T2]
Gene(s)
Description Species Link Ref.
Apolipoprotein B (ApoB) Homo sapiens EntrezGene: 338 [G1][G2]
::References
ID [1]
Authors Pontrelli L, Sidiropoulos KG, Adeli K.
Title Translational control of apolipoprotein B mRNA: regulation via cis elements in the 5' and 3' untranslated regions.
Citation Biochemistry 2004 Jun 1; 43(21): 6734-44
Year 2004
ID [2]
Authors Sidiropoulos KG, Zastepa A, Adeli K.
Title Translational control of apolipoprotein B mRNA via insulin and the protein kinase C signaling cascades: evidence for modulation of RNA-protein interactions at the 5'UTR.
Citation Arch. Biochem. Biophys. 2007 Mar 1; 459(1): 10-9
Year 2007
ID [U1]
Authors Pontrelli L, Sidiropoulos KG, Adeli K.
Title Translational control of apolipoprotein B mRNA: regulation via cis elements in the 5' and 3' untranslated regions.
Citation Biochemistry 2004 Jun 1; 43(21): 6734-44
Year 2004
ID [U2]
Authors Sidiropoulos KG, Zastepa A, Adeli K.
Title Translational control of apolipoprotein B mRNA via insulin and the protein kinase C signaling cascades: evidence for modulation of RNA-protein interactions at the 5'UTR.
Citation Arch. Biochem. Biophys. 2007 Mar 1; 459(1): 10-9
Year 2007
ID [T1]
Authors Pontrelli L, Sidiropoulos KG, Adeli K.
Title Translational control of apolipoprotein B mRNA: regulation via cis elements in the 5' and 3' untranslated regions.
Citation Biochemistry 2004 Jun 1; 43(21): 6734-44
Year 2004
ID [T2]
Authors Sidiropoulos KG, Zastepa A, Adeli K.
Title Translational control of apolipoprotein B mRNA via insulin and the protein kinase C signaling cascades: evidence for modulation of RNA-protein interactions at the 5'UTR.
Citation Arch. Biochem. Biophys. 2007 Mar 1; 459(1): 10-9
Year 2007
ID [G1]
Authors Pontrelli L, Sidiropoulos KG, Adeli K.
Title Translational control of apolipoprotein B mRNA: regulation via cis elements in the 5' and 3' untranslated regions.
Citation Biochemistry 2004 Jun 1; 43(21): 6734-44
Year 2004
ID [G2]
Authors Sidiropoulos KG, Zastepa A, Adeli K.
Title Translational control of apolipoprotein B mRNA via insulin and the protein kinase C signaling cascades: evidence for modulation of RNA-protein interactions at the 5'UTR.
Citation Arch. Biochem. Biophys. 2007 Mar 1; 459(1): 10-9
Year 2007