| ID |
UX0001 |
|
| Creation Date |
02 September 2004 |
| Updating Date |
07 August 2007 |
|
| Standard Name |
Translation inhibitor ADRB2 uORF |
| UTRSite Pattern |
ATGMRKCTTCCMGGHGYYCGCYYSCKGMCSGCNGMGCCSCNYCSKRGGTSCRCYCGCTGA |
|
| UTR Region |
All |
|
| Description |
ADRB2 is a membrane-integrated protein that mediate the effects of catecholamines at the cell surface. The 5' leader region contains a uORF encoding a 19-amino acid peptide. uORF inhibits receptor translation. Indeed the á2 receptor uORF ATG codon was mutated and approximately 2-fold more receptor was expressed respect from wild type. Likely a secondary structures located downstream from the upstream start codon enhance translation initiation by slowing ribosome scanning. The peptide encoded (BUP) by the uORF may form a complex with mRNA inhibiting translation. This uORF has been characterized in human, and is also conserved in mouse, rat, cow and dog mRNAs. |
|
|
|
| Feature Key |
uORF |
|
| UTR(s) |
| Description |
Species |
Link |
Ref. |
| Adrenergic receptor beta 2 (ADRB2) |
Homo sapiens |
UTRef: BR032509 |
[U1] |
|
| Transcript(s) |
|
| Gene(s) |
| Description |
Species |
Link |
Ref. |
| Adrenergic receptor beta 2 (ADRB2) |
Homo sapiens |
EntrezGene: 154 |
[G1] |
|
|
| Binding Protein(s) |
| Description |
Species |
Link |
Ref. |
| COMM domain containing protein 3 (bup protein) (pil protein) |
Homo sapiens |
UniProt: Q9UBI1 |
[B1] |
|
|
| ID |
[1] |
| Authors |
Parola AL, Kobilka BK |
| Title |
The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor |
| Citation |
J Biol Chem. 1994 Feb 11;269(6):4497-505 |
| Year |
1994 |
| ID |
[U1] |
| Authors |
Parola AL, Kobilka BK |
| Title |
The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor |
| Citation |
J Biol Chem. 1994 Feb 11;269(6):4497-505 |
| Year |
1994 |
| ID |
[T1] |
| Authors |
Parola AL, Kobilka BK |
| Title |
The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor |
| Citation |
J Biol Chem. 1994 Feb 11;269(6):4497-505 |
| Year |
1994 |
| ID |
[G1] |
| Authors |
Parola AL, Kobilka BK |
| Title |
The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor |
| Citation |
J Biol Chem. 1994 Feb 11;269(6):4497-505 |
| Year |
1994 |
| ID |
[B1] |
| Authors |
Parola AL, Kobilka BK |
| Title |
The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor |
| Citation |
J Biol Chem. 1994 Feb 11;269(6):4497-505 |
| Year |
1994 |
