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Signal Manager :: View

::General Information
ID UX0001
Creation Date 02 September 2004
Updating Date 07 August 2007
Standard Name Translation inhibitor ADRB2 uORF
UTRSite Pattern
ATGMRKCTTCCMGGHGYYCGCYYSCKGMCSGCNGMGCCSCNYCSKRGGTSCRCYCGCTGA
::Taxonomy
UTR Region All
::Description
Description

ADRB2 is a membrane-integrated protein that mediate the effects of catecholamines at the cell surface. The 5' leader region contains a uORF encoding a 19-amino acid peptide. uORF inhibits receptor translation. Indeed the 2 receptor uORF ATG codon was mutated and approximately 2-fold more receptor was expressed respect from wild type. Likely a secondary structures located downstream from the upstream start codon enhance translation initiation by slowing ribosome scanning. The peptide encoded ......

::Features
Feature Key uORF
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
Adrenergic receptor beta 2 (ADRB2) Homo sapiens UTRef: BR032509 [U1]
Transcript(s)
Description Species Link Ref.
Adrenergic receptor beta 2 (ADRB2) Homo sapiens RefSeq: NM_000024 [T1]
Gene(s)
Description Species Link Ref.
Adrenergic receptor beta 2 (ADRB2) Homo sapiens EntrezGene: 154 [G1]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
COMM domain containing protein 3 (bup protein) (pil protein) Homo sapiens UniProt: Q9UBI1 [B1]
::References
ID [1]
Authors Parola AL, Kobilka BK
Title The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor
Citation J Biol Chem. 1994 Feb 11;269(6):4497-505
Year 1994
ID [U1]
Authors Parola AL, Kobilka BK
Title The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor
Citation J Biol Chem. 1994 Feb 11;269(6):4497-505
Year 1994
ID [T1]
Authors Parola AL, Kobilka BK
Title The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor
Citation J Biol Chem. 1994 Feb 11;269(6):4497-505
Year 1994
ID [G1]
Authors Parola AL, Kobilka BK
Title The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor
Citation J Biol Chem. 1994 Feb 11;269(6):4497-505
Year 1994
ID [B1]
Authors Parola AL, Kobilka BK
Title The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor
Citation J Biol Chem. 1994 Feb 11;269(6):4497-505
Year 1994