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::General Information
ID UX0002
Creation Date 02 September 2004
Updating Date 07 August 2007
Standard Name Polyamines-dependent translation inhibitor AMD1 uORF
UTRSite Pattern
0...6 GGCGAYATTAGCTAG
::Taxonomy
UTR Region All
::Description
Description

S-Adenosylmethionine Decarboxylase is a key regulatory enzyme which catalyzes a step in the biosynthesis of the polyamines spermidine and spermine. This step is regulated by a feed-back mechanism dependent on the level of polyamines in the cell. The mRNA of AMD1 contains an uORF encoding a small hexapeptide (MAGDIS) that interacts with the peptidil transferase complex, inhibiting the release of the ribosome from the translational apparatus. Site-directed mutagenesis has been used to demonstrate that the sequence of the uORF peptide is important for the inhibitory regulation of AMD1.

This uORF has been characterized in human, and is also conserved in mouse, cow, cock and zebrafish mRNAs.

::Features
Feature Key uORF
::Transcript(s) / Gene(s)
UTR(s)
Description Species Link Ref.
Adenosylmethionine decarboxylase 1 (AMD1) Homo sapiens UTRef: BR283949 [U1][U2][U3]
Transcript(s)
Description Species Link Ref.
Adenosylmethionine decarboxylase 1 (AMD1) Homo sapiens RefSeq: NM_001634 [T1][T2][T3]
Gene(s)
Description Species Link Ref.
Adenosylmethionine decarboxylase 1 (AMD1) Homo sapiens EntrezGene: 262 [G1][G2][G3]
::Protein(s)
Binding Protein(s)
Description Species Link Ref.
s-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (AMD1) Homo sapiens UniProt: P17707 [B1][B2][B3]
::References
ID [1]
Authors Alexa Raney, G. Lynn Law, Gregory J.Mize, David R.Morris
Title Regulated translation termination at the upstream open reading frame in s-adenosylmethionine decarboxylase mRNA
Citation J. Biol. Chem., Vol. 277, Issue 8, 5988-5994, February 22, 2002
Year 2002
ID [2]
Authors G. Lynn, Alexa Raney, Carrie Heusner and David R. Morris
Title Polyamine regulation of ribosome pausing at the upstream open reading frame of S-Adenosylmethionine decarboxylase
Citation J. Biol. Chem., Vol. 276, Issue 41, 38036-38043, October 12, 2001
Year 2001
ID [3]
Authors Alexa Raney, Anita C. Baron, Gregory J. Mize, G. Lynn Law, David Morris
Title In vitro translation of the upstream open reading frame in the mammalian mRNA encoding S-Adenosylmethionine decarboxylase.
Citation J. Biol. Chem., Vol. 275, Issue 32, 24444-24450, August 11, 2000
Year 2000
ID [U1]
Authors Alexa Raney, G. Lynn Law, Gregory J.Mize, David R.Morris
Title Regulated translation termination at the upstream open reading frame in s-adenosylmethionine decarboxylase mRNA
Citation J. Biol. Chem., Vol. 277, Issue 8, 5988-5994, February 22, 2002
Year 2002
ID [U2]
Authors G. Lynn, Alexa Raney, Carrie Heusner and David R. Morris
Title Polyamine regulation of ribosome pausing at the upstream open reading frame of S-Adenosylmethionine decarboxylase
Citation J. Biol. Chem., Vol. 276, Issue 41, 38036-38043, October 12, 2001
Year 2001
ID [U3]
Authors Alexa Raney, Anita C. Baron, Gregory J. Mize, G. Lynn Law, David Morris
Title In vitro translation of the upstream open reading frame in the mammalian mRNA encoding S-Adenosylmethionine decarboxylase.
Citation J. Biol. Chem., Vol. 275, Issue 32, 24444-24450, August 11, 2000
Year 2000
ID [T1]
Authors Alexa Raney, G. Lynn Law, Gregory J.Mize, David R.Morris
Title Regulated translation termination at the upstream open reading frame in s-adenosylmethionine decarboxylase mRNA
Citation J. Biol. Chem., Vol. 277, Issue 8, 5988-5994, February 22, 2002
Year 2002
ID [T2]
Authors G. Lynn, Alexa Raney, Carrie Heusner and David R. Morris
Title Polyamine regulation of ribosome pausing at the upstream open reading frame of S-Adenosylmethionine decarboxylase
Citation J. Biol. Chem., Vol. 276, Issue 41, 38036-38043, October 12, 2001
Year 2001
ID [T3]
Authors Alexa Raney, Anita C. Baron, Gregory J. Mize, G. Lynn Law, David Morris
Title In vitro translation of the upstream open reading frame in the mammalian mRNA encoding S-Adenosylmethionine decarboxylase.
Citation J. Biol. Chem., Vol. 275, Issue 32, 24444-24450, August 11, 2000
Year 2000
ID [G1]
Authors Alexa Raney, G. Lynn Law, Gregory J.Mize, David R.Morris
Title Regulated translation termination at the upstream open reading frame in s-adenosylmethionine decarboxylase mRNA
Citation J. Biol. Chem., Vol. 277, Issue 8, 5988-5994, February 22, 2002
Year 2002
ID [G2]
Authors G. Lynn, Alexa Raney, Carrie Heusner and David R. Morris
Title Polyamine regulation of ribosome pausing at the upstream open reading frame of S-Adenosylmethionine decarboxylase
Citation J. Biol. Chem., Vol. 276, Issue 41, 38036-38043, October 12, 2001
Year 2001
ID [G3]
Authors Alexa Raney, Anita C. Baron, Gregory J. Mize, G. Lynn Law, David Morris
Title In vitro translation of the upstream open reading frame in the mammalian mRNA encoding S-Adenosylmethionine decarboxylase.
Citation J. Biol. Chem., Vol. 275, Issue 32, 24444-24450, August 11, 2000
Year 2000
ID [B1]
Authors Alexa Raney, G. Lynn Law, Gregory J.Mize, David R.Morris
Title Regulated translation termination at the upstream open reading frame in s-adenosylmethionine decarboxylase mRNA
Citation J. Biol. Chem., Vol. 277, Issue 8, 5988-5994, February 22, 2002
Year 2002
ID [B2]
Authors G. Lynn, Alexa Raney, Carrie Heusner and David R. Morris
Title Polyamine regulation of ribosome pausing at the upstream open reading frame of S-Adenosylmethionine decarboxylase
Citation J. Biol. Chem., Vol. 276, Issue 41, 38036-38043, October 12, 2001
Year 2001
ID [B3]
Authors Alexa Raney, Anita C. Baron, Gregory J. Mize, G. Lynn Law, David Morris
Title In vitro translation of the upstream open reading frame in the mammalian mRNA encoding S-Adenosylmethionine decarboxylase.
Citation J. Biol. Chem., Vol. 275, Issue 32, 24444-24450, August 11, 2000
Year 2000