Signal Manager :: View

::General Information
ID	UX0008
Creation Date	02 September 2004
Updating Date	02 September 2004
Standard Name	Translation inhibitor HERBB2 uORF
UTRSite Pattern	ATGGGGCCGGAGCCGCAGTGA M G P E P Q *
::Taxonomy
UTR Region	All
::Description
Description	Overexpression of HER-2 (neu, erbB-2) results in cellular transformation and is associated with a variety of human cancers. The HER-2 oncogene encodes a 185-kDa transmembrane receptor tyrosine kinase. Its expression is regulated at the translational level. There are two distinct translational mechanisms controling erbB-2 protein expression: the first is a cell type-dependent mechanism that causes increased erbB-2 translation while the second is a cell type-independent repression of downstream ......
Description
::Features
Feature Key	uORF
::References
ID	[1]
Authors	Stephanie J. Child, Melanie K. Miller, and Adam P. Geballe
Title	Translational control by an upstream open reading frame in the HER-2/neu transcript
Citation	J Biol Chem. 1999 Aug 20;274(34):24335-41.
Year	1999