Signal Manager :: View

::General Information
ID	UX0010
Creation Date	02 September 2004
Updating Date	02 September 2004
Standard Name	Translation inhibitor CDKN1B uORF
UTRSite Pattern	ATGGATCTCCTCCTCTGTTTAAATAGACTCGCCGTGTCAATCATTTTCTTCTTCGTCAGCCTCCCTTCCACCGCCATATTGGGCCACTAA M D L L L C L N R L A V S I I F F F V S L P S T A I L G H *
::Taxonomy
UTR Region	All
::Description
Description	The Cdk inhibitory protein p27 play a key role in regulating Cdk activity during G1 progression and in growth arrest. Level of the inhibitory protein oscillate during the cell cycle and peak in G1 phase. Under most conditions investigated, p27 oscillations are the result of post-trascriptional mechanisms that include translational control and regulated protein stability. Since p27 transcripts of various length have been described that differ in length of their 5'UTR between 152 and 575 nucleot......
Description
::Features
Feature Key	uORF
::References
ID	[1]
Authors	Kullmann M, Gopfert U, Siewe B, Hengst L.
Title	ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.
Citation	Genes Dev. 2002 Dec 1;16(23):3087-99.
Year	2002
ID	[2]
Authors	Gopfert U, Kullmann M, Hengst L.
Title	Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF.
Citation	Hum Mol Genet. 2003 Jul 15;12(14):1767-79
Year	2003