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Welcome to UTRSite

UTRSite is a collection of functional sequence patterns located in 5' or 3' UTR sequences.

Understanding the basic mechanisms of cell growth, differentiation and response to environmental stimuli, i.e. the program controlling the temporal and spatial order of molecular events, is becoming a real challenge in molecular biology. Indeed, although most of the regulatory elements are thought to be embedded in the non-coding part of the genomes, nucleotide databases are biased by the presence of expressed sequences mostly corresponding to the protein coding portion of the genes.

Among non-coding regions, the 5' and 3' untranslated regions (5'-UTR and 3'-UTR) of eukaryotic mRNAs have often been experimentally demonstrated to contain sequence elements crucial for many aspects of gene regulation and expression.